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CNS Penetration Ability: A Critical Factor for Drugs in the Treatment of SARS-CoV-2 Brain Infection.

Danta, Chhanda Charan.

ACS Chem Neurosci ; 11(15): 2137-2144, 2020 08 05.

Article in English | MEDLINE | ID: covidwho-636269

ABSTRACT

Now, it has been evidenced that Covid19 (SARS-CoV-2) infects the brain tissues. Along with this, a challenge has been raised for research professionals to find effective drugs for its treatment since the recent spread of this virus from Wuhan, China. Targeting the treatment of brain infection, it has also been a challenge that the clinical drug should have good CNS penetration ability to cross the blood-brain barrier.

Subject(s)

Betacoronavirus , Blood-Brain Barrier/metabolism , Brain/metabolism , Coronavirus Infections/drug therapy , Coronavirus Infections/metabolism , Pneumonia, Viral/drug therapy , Pneumonia, Viral/metabolism , Adenosine Monophosphate/administration & dosage , Adenosine Monophosphate/analogs & derivatives , Adenosine Monophosphate/metabolism , Alanine/administration & dosage , Alanine/analogs & derivatives , Alanine/metabolism , Animals , Anti-Inflammatory Agents/administration & dosage , Anti-Inflammatory Agents/metabolism , Antiviral Agents/administration & dosage , Antiviral Agents/metabolism , Betacoronavirus/drug effects , Blood-Brain Barrier/drug effects , Blood-Brain Barrier/virology , Brain/drug effects , COVID-19 , Central Nervous System Agents/administration & dosage , Central Nervous System Agents/metabolism , Drug Evaluation, Preclinical/methods , Humans , Methylprednisolone/administration & dosage , Methylprednisolone/metabolism , Pandemics , SARS-CoV-2 , Treatment Outcome

ABSTRACT

Subject(s)

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